ProKinO: Protein Kinase Ontology Browser
The University of Georgia
About: ProKinO Ontology

Current version: 2.0
Date: 2019/01/18

The Protein Kinase Ontology (ProKinO), is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases. The conceptual representation of such diverse information in one place enables not only rapid discovery of significant information related to a specific protein kinase, but also enables large scale integrative analysis of the protein kinase family.

ProKinO is a collaborative effort between the Evolutionary Systems Biology Group Lab of Dr. Natarajan Kannan at the Biochemistry and Molecular Biology Department and Dr. Krys J. Kochut's lab at the Computer Science Department, both at University of Georgia, Athens, USA. Gurinder Gosal, also at UGA, created the software system to automatically populate ProKinO from the selected data sources. The population system has been modified and is currently maintained by Shima Dastgheib, Computer Science, UGA.

Publications:

McSkimming, D.I., Dastgheib, S., Talevich, E., Narayanan, A., Katiyar, S., Taylor, S.S., Kochut, K.J., Kannan, N., 2015, "ProKinO: a unified resource for mining the cancer kinome." Human Mutation 36(2):175-86. doi:10.1002/humu.22726.

Gosal, G., Kochut, K.J., Kannan, N., 2011 "ProKinO: An Ontology for Integrative Analysis of Protein Kinases in Cancer." PLoS ONE 6(12):e28782. doi:10.1371/journal.pone.0028782

Gosal, G., Kannan, N. Kochut, K.J., "ProKinO: A Framework for Protein Kinase Ontology," in Proceedings of the 2011 IEEE International Conference on Bioinformatics and Biomedicine (BIBM), Location: Atlanta, GA, USA, pp. 550-555.